Symptoms/signs of multiple CNS sites involvement at onset are associated with shorter time to EDSS 6 and/or SP phase compared to monofocal presentation
MS patients with pyramidal and/or cerebellar involvement at onset reach EDSS 6 more rapidly compared to patients with optic nerve or sensory symptoms (no influence on time to SP MS)
Shorter time to second attack and higher relapse number in first 2–5 years after onset are associated with more rapid progression to EDSS 6 and transition to the SP phase