Association of IL-4-590 C>T and IL-13-1112 C>T Gene Polymorphisms with the Susceptibility to Type 2 Diabetes Mellitus

Table 1

IL-4-590 C>T and IL-13-1112 C>T genetic variants among Egyptian cases with T2DM compared to controls.

	Cases n (%)	Controls n (%)
IL-4-590 C>T
CC	14 (10.4)	30 (43.48)
CT	115 (85.2)	33 (47.83)
TT	6 (4.4)	6 (8.69)
Dominant
TT+CT  versus CC	𝑃=0.000^∗∗, OR=6.65	95% CI = 3.4–13.2
Codominant
CT versus CC	𝑃=0.000^∗∗, OR=7.50	95% CI = 3.7–14.9
TT versus CC	𝑃=0.400, OR=2.14	95%  CI = 0.6–7.7
Recessive
TT versus CT+CC	𝑃=0.400, OR=0.49	95%  CI = 0.2–1.5
Overdominant
CT versus CC+TT	𝑃=0.000^∗∗, OR=6.27	95% CI = 3.3–11.9
HWE	𝜒^2=68.0,  𝑃=0.000^∗∗	𝜒^2=0.54, 𝑃=0.462
IL-13-1112 C>T
CC	28 (20.7)	42 (56.00)
CT	103 (76.3)	31 (41.33)
TT	4 (3.0)	2 (2.67)
Dominant
TT+CT versus CC	𝑃=0.000^∗∗, OR=4.86	95% CI = 2.7–8.8
Codominant
CT versus CC	𝑃=0.000^∗∗, OR=4.98	95% CI = 2.7–9.1
TT  versus CC	𝑃=0.400, OR=3.0	95%  CI = 0.6–16.4
Recessive
TT versus CT+CC	𝑃=0.760, OR=1.11	95%  CI = 0.2–6.2
Overdominant
CT  versus CC+TT	𝑃=0.000^∗∗, OR=4.57	95%  CI = 2.5–8.2
HWE	𝜒^2=44.7, 𝑃=0.000^∗∗	𝜒^2=1.8, 𝑃=0.180

Some subjects could not be genotyped for technical reasons.
^∗∗𝑃 highly significant < 0.001; HVE: Hardy Weinberg Equilibrium.