| | The characteristics | All subjects n = 44 |
| | Clinical and laboratory data | | Age (years), mean ± SD | 39.5 ± 13.3 | | Sex, n (%) | | Male (%) | 4 (9.1) | | Female (%) | 40 (90.9) | | SBP (mmHg), median (IQR) | 101 (95–120) | | DBP (mmHg), median (IQR) | 70 (70–80) | | Peripheral O2 saturation (%), median (IQR) | 96 (93–98) | | W.H.O functional class, n (%) | | I | 7 (15.9) | | II | 35 (79.5) | | III | 2 (4.5) | | Haemoglobin (g/dL), mean ± SD | 13.4 ± 1.6 | | Hematocrit (%), mean ± SD | 40.0 ± 4.8 | | Creatinine (g/dL), mean ± SD | 0.8 ± 0.2 | | Endothelin-1 (pg/dL), mean ± SD | 674.29 ± 405.28 | | Prostacyclin (pg/dL), median (IQR) | 413.51 (190.13–1280.89) | | Nitric oxide (µmol/L), mean ± SD | 325.49 ± 77.56 |
| | Echocardiography data | | Minimum ASD diameter (cm), mean ± SD | 2.5 ± 0.6 | | Maximum ASD diameter (cm), mean ± SD | 2.7 ± 0.9 | | Right atrial dimension (cm), mean ± SD | 4.8 ± 0.7 | | Right ventricle dimension (cm), mean ± SD | 4.7 ± 0.5 | | Left ventricle ejection fraction (%),mean ± SD | 71.2 ± 10.1 | | TAPSE (cm), mean ± SD | 2.5 ± 0.5 | | TVRG (mmHg), mean ± SD | 78.0 ± 28.5 | | RVSP (mmHg), mean ± SD | 85.4 ± 28.2 | | Left atrial dimension (cm), median (IQR) | 3.3 (2.9–3.7) | | LVIDd (cm), median (IQR) | 3.5 (3.1–3.8) | | Tricuspid valve regurgitation, n (%) | | Mild | 3 (6.8) | | Moderate | 24 (54.5) | | Severe | 17 (38.6) | | Shunt direction, n (%) | | Left to right | 27 (61.4) | | Bidirectional | 17 (38.6) |
| | Hemodynamics RHC data | | Mean pressure (mmHg) | | Aorta, mean ± SD | 103.6 ± 15.0 | | RV systolic, median (IQR) | 86.0 (64.0–103.0) | | Pulmonary artery, mean ± SD | 51.0 ± 15.2 | | Pulmonary artery wedge pressure (mmHg) | 8.0 ± 4.4 | | O2 saturation (%) | | Aorta, median (IQR) | 91.0 (85.0–94.0) | | Mixed vein, median (IQR) | 60.6 (55.0–64.0) | | Left atrium, median (IQR) | 90.5 (85.0–93.0) | | Right atrium, mean ± SD | 73.0 ± 9.4 | | Pulmonary vein, median (IQR) | 95.5 (93.0–96.5) | | Pulmonary artery, mean ± SD | 77.0 ± 10.0 | | PVR (Woods unit), median (IQR) | 12.7 (3.9–21.3) | | Flow ratio, median (IQR) | 1.7 (1.3–2.8) | | PAH severity, n (%) | 10 (22.7) | | Mild | 13 (29.5%) | | Moderate | 22 (50.0%) | | Severe | 9 (20.5%) |
|
|
IQR: interquartile range, SBP: systolic blood pressure, DBP: diastolic blood pressure, ASD: atrial septal defect, TAPSE: tricuspid annular plane systolic excursion, TVRG: tricuspid valve regurgitant gradient, RVSP: right ventricular systolic pressure, LVIDd: left ventricle internal diastolic diameter, RHC: right heart catheterization, PVR: pulmonary vascular resistance, mPAP: mean pulmonary artery pressure, PAH: pulmonary artery hypertension, and RV: right ventricle.
|
