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Study | Model | Ischemic protocol | Duration/onset of diabetes | Substrates | Model of diabetes | End points |
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Jones et al. (1999) [26] | db/db mouse | In vivo non recovery, 30 min regional ischemia/2 h reperfusion | In-bred strain | In vivo substrates | Type II diabetes | Infarction |
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Kersten et al. (2000) [27] | Dog, Alloxan (40 mg/kg) and STZ (25 mg/kg) | In vivo non recovery, 60 min regional ischemia/3 h reperfusion | 3 weeks | In vivo substrates | Type I diabetes | Infarction |
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Kersten et al. (2000) [27] | Dog, Dextrose 15% to cause acute hyperglycaemia | In vivo non recovery, 60 min regional ischemia/3 h reperfusion | 70 mins | In vivo substrates | Type I diabetes | Infarction |
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Lefer et al. (2001) [28] | db/db mouse | In vivo non recovery, 30 min regional ischemia/2 h reperfusion | In-bred strain | In vivo substrates | Type II diabetes | Infarction |
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Fiordaliso et al. (2001) [29] | Rat cardiomyocytes | — | 1, 2, and 4 days of 25 mmol/L incubation in medium | — | Type I diabetes | Cell death |
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Marfella et al. (2002) [30] | Sprague-Dawley Rat, STZ (70 mg/kg i.v) | In vivo non recovery, 25 min regional ischemia/2 h reperfusion | 9 days | In vivo substrates | Type I diabetes | Infarction and protein expression |
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Marfella et al. (2002) [30] | Sprague-Dawley Rat, isolated heart | Langendorff isolated heart, 25 min regional ischemia/2 hr reperfusion | — | 33.3 mmol/L glucose | Type I diabetes | Infarction and protein expression |
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Ebel et al. (2003) [31] | Rabbit- 50% Dextrose infused 30 min prior to ischemia until reperfusion normoglycaemic rat-under intravenous | In vivo non recovery, 30 min regional ischemia/2 h reperfusion | hyperglycemia of 600 mgd1-1 throughout ischemia | In vivo substrates | Type I diabetes | Infarction |
Su et al. (2007) [32] | infusion at a rate of 4 mL·kg–1·h–1: of glucose 500 g/l during ischemia, saline during reperfusion | In vivo non recovery, 30 min regional ischemia/6 h reperfusion | — | In vivo substrates | Type I diabetes | Infarction, apoptosis and kinase expression |
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Desrois et al. (2010) [33] | Aging Goto Kakizaki Rat, male | Langendorff isolated heart, 32 min low flow global ischemia/32 min reperfusion | In-bred strain | 1.2 mM palmitate, 3% albumin, 11 mM glucose, 3 U/l insulin, 0.8 mM lactate, and 0.2 mM pyruvate. | Type II diabetes | Myocardial function |
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