Long-Term Costs of Ischemic Stroke and Major Bleeding Events among Medicare Patients with Nonvalvular Atrial Fibrillation

Table 1

Study codes.

Condition	ICD-9 codes	CPT codes
Patient identification
Atrial fibrillation	427.31
Valvular conditions	Procedure codes: 35.0, 35.00–35.04, 35.1, 35.10–35.14, 35.2, 35.20–35.28, 35.96	33400, 33401, 33403, 33405, 33406, 33410–33415, 33417, 33420, 33422, 33425–33427, 33430, 33460, 33463–33465, 33468, 33470, 33472, 33474–33476, 33478, 33496, 33600, 33602
Outcomes
Ischemic stroke	433.x1, 434.x1, 436, 437.1, 437.9
Major bleeding
Intracranial hemorrhage	430, 431, 432
Other major bleeds	423.0, 455.2, 455.5, 455.8, 456.0, 456.2, 459.0, 530.7, 530.8, 531.0, 531.2, 531.4, 531.6, 532.0, 532.2, 532.4, 532.6, 533.0, 533.2, 533.4, 533.6, 534.0, 534.2, 534.4, 534.6, 562.0, 562.1, 569.3, 569.85, 578, 599.7, 626.2, 626.6, 719.1, 784.7, 786.3, 852, 853
CHA2DS2-VASc components
Cardiac failure	398.91, 402.x1, 404.x3, 425, 428
Hypertension^1	362.11, 401, 402, 403, 404, 405
Diabetes mellitus^1	250, 357.2, 362.0, 366.41
Prior TIA^2	362.34, 435
Vascular disease	410, 411, 412, 413, 414, 440, 441, 442, 443, 444, 445; Procedure codes: 00.66, 36.0, 36.1, 39.25	33510–33545, 34051, 34151, 34201, 34203, 34800–34834, 34900, 35081–35103, 35131, 35132, 35141, 35142, 35151, 35152, 35331, 35341, 35351, 35355, 35361, 35363, 35371, 35372, 35381, 35450, 35452, 35454, 35456, 35459, 35470, 35471, 35472, 35473, 35474, 35480, 35481, 35482, 35483, 35485, 35490, 35491, 35492, 35493, 35495, 35521, 35531, 35533, 35541, 35546, 35546, 35548, 35549, 35551, 35556, 35558, 35563, 35565, 35566, 35571, 35583, 35585, 35587, 35621, 35623, 35646, 35647, 35651, 35654, 35656, 35661, 35663, 35665, 35666, 35671, 92980, 92981, 92982, 92984
HAS-BLED components
Hypertension^1	362.11, 401, 402, 403, 404, 405
Abnormal renal function	582, 583, 585, 586
Abnormal liver function	570, 571, 572, 573, 790.4
Prior TIA^2	362.34, 435
Excessive alcohol use	291.0, 291.1, 291.2, 303, 305.0, 535.3, V11.3

Note: With the exception of valvular conditions, ICD-9 codes reported as 3 digits will include all 4-digit and 5-digit codes beginning with the same 3 digits. For 4-digit codes, any 5-digit code beginning with the same 4 digits will also be included. ICD-9 codes reported are diagnosis codes unless otherwise indicated.
¹Patient must have at least 2 diagnoses documented in the same calendar quarter to be considered as having the condition.
²Risk score definition includes prior stroke, but with the exclusion of patients with prior stroke, only prior TIA is applicable in this study.