Progression of Left Ventricular Dysfunction and Remodelling under Optimal Medical Therapy in CHF Patients: Role of Individual Genetic Background
Table 1
Baseline characteristics of study population.
Variable
Age (yrs)
Male gender (%)
107 (82)
NYHA functional class
SBP (mm Hg)
DBP (mm Hg)
Heart Rate (beats/min)
S-Na+ (mEq/L)
S-Creatinine (μmol/L)
Hb (g/dL)
Treatment (%)
Diuretics
117 (90)
ACE inhibitors/ARBs
127 (97)
Beta blockers
110 (84)
Spironolactone
31 (24)
Statins
90 (69)
Echocardiography
LVEF (%)
LVEDV (mL)
LVESV (mL)
Genotypes,
ACE II/ ID, DD
20/111
β1 AR389 ≥1 Arg/GlyGly
31/100
β2 16 GlyGly/ ≥ 1 Arg
57/74
β2 27 GlnGln/ ≥ 1 Glu
51/80
Data are expressed as mean ± SD or number (%). Abbreviations: NYHA: New York Heart Association; SBP: systolic blood pressure; DBP: diastolic blood pressure; Hb: hemoglobin; ARBs: angiotensin II receptor blockers; LVEF: left ventricular ejection fraction; LVEDV: left ventricular end diastolic volume; LVESV: left ventricular end systolic volume.