Review Article
Noninvasive Home Mechanical Ventilation for Stable Hypercapnic COPD: A Clinical Respiratory Review from Canadian Perspectives
Table 1
Landmark RCTs of high-intensity NIV.
| | | Kohnlein [12] | Struik [24] | Murphy [11] |
| | N | 195 | 201 | 116 | | Age | 62 vs. 64 | 64 vs. 63.5 | 66.4 vs. 67.1 | | Post-AECOPD | No | Yes | Yes | | Follow-up | 12 months | 12 months | 12 months | | BMI (kg/m2) | 24.8 vs. 24.5 | 24.6 vs. 24.8 | 21.5 vs. 22.2 | | FEV1 (% predicted) | 26 vs. 27.5 | 25.6 vs. 25.7 | 24 vs. 22.9 | | Inclusion minimal PaCO2 criteria (mmHg) | 51.9 | 45 | 53 | | Baseline PaCO2 (mmHg) | 58.5 vs. 57.8 | 59.3 vs. 57.8 | 59 | | Final IPAP/EPAP (cm H2O) | 21.6/4.8 | 19.2/4.8 | 24/4 | | Final backup rate (breaths/minute) | 14 | 15 | 14 | | Adherence (hour/night) | 5.9 | 6.9 | 7.6 | | Outcome | LTH-NIV improved 1-year all-cause mortality | LTH-NIV did not improve time to readmission or death | LTH-NIV improved time to readmission or death |
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Compared values are intervention vs. control. Data are shown as the mean unless otherwise indicated. |
