Effects of Conservative Oxygen Therapy versus Conventional Oxygen Therapy on the Mortality in ICU Patients: A Meta-Analysis

Table 1

Basic characteristics of included studies.

Study	Year	Participants	Nr.		Intervention assignments		Outcome
			Conservative group	Conventional group	Conservative group	Conventional group
Panwar et al. [16]	2016	Mechanically ventilated patients	52	51	SpO2 0.88–0.92	SpO2 ≥ 96%	①②③④
Schjørring et al. [17]	2021	Patients with ARDS	1441	1447	PaO2 60 mmHg	PaO2 90 mmHg	②⑤
Asfar et al. [18]	2017	Patients with septic shock	217	217	SpO2 0.88–0.95	FiO2 of 1.0 for 24 h	①②③⑤⑥⑦
Girardis et al. [10]	2016	ICU patients	216	218	SpO2 0.94–0.98 or PaO2 70–100 mmHg	PaO2 up to 150 mmHg or SpO2 0.97–1.0	①③④⑤⑥
Mackle et al. [15]	2020	Mechanically ventilated patients	484	481	SpO2 90–97%	No specific limiting FiO2 or SpO2	②
Yang and Wang [19]	2021	Mechanically ventilated patients	55	51	PaO2 70∼100 mmHg or SpO2 0.90∼0.92	PaO2 > 150 mmHg or SpO2 > 0.96	①③④⑤⑥⑦
Gelissen et al. [20]	2021	Critically ill patients with SIRS	205	195	PaO2 60–90 mmHg	PaO2 105–135 mmHg	①③⑤
Barrot et al. [14]	2020	Patients with ARDS	99	102	PaO2 55–70 mmHg; SpO2 88–92%	PaO2 90–105 mmHg; SpO2 ≥ 96%	①②⑤⑥
Yang et al. [21]	2019	ICU patients	100	114	SpO2 90–95%	SpO2 96–100%	①
Martin et al. [22]	2021	Mechanically ventilated patients	17	17	SpO2 88–92%	SpO2 96%	①②

① Short-term mortality rate (28-day mortality rate or ICU mortality rate), ② 90-day mortality rate, ③ ICU length of stay, ④ hospital length of stay, ⑤ incidence of new ICU organ dysfunction, ⑥ incidence of new ICU infection, and ⑦ incidence of ICUAW.