|
| Compounds | Model | EMT-related target |
|
| Glycyrrhizin [52] | OVA-induced asthma in mice | TGF-β1/Smad |
| Diosmetin [53, 54] | TGF-induced HBE16 cells | PI3K/Akt, MAPK |
| Sinomenine [55] | OVA-induced asthma in mice | TGF-β1 |
| Emodin [56] | Rat type-II alveolar epithelial cells (RLE-6TN) | Notch-1, collagen I, α-SMA |
| Amygdalin [57] | COPD mice and BEAS-2B cells exposed to smoke | TGF-β/Smad3, |
| Hexamethoxy flavanone-o-[rhamnopyranosyl-(1,4)-rhamnopyranoside (HMFRR) [58] | A549 | EGFR, COX-2, MMP-2, MMP-9, STAT3/NF-κB/COX-2, EGFR/PI3K/Akt |
| Tetrandrine [59] | OVA-induced asthma in male Wistar rats | TGF-β1/Nrf-2/HO-1 |
| Naringenin [60] | Mycoplasma pneumoniae (MP)-induced lung injury | IL-6, IL-1β, TNF-α, and TGF-β |
| Icariin [61] | OVA-induced asthma in mice | MAPK/Erk |
| Nodakenin [62] | OVA-induced asthma in mice | IL-4, IL-5, IL-13, MMP2/9, and NF-κB |
| Dioscin [63] | OVA-induced asthma in mice TGF-induced HBE16 | TGF-β/Smad |
| Galangin [64] | OVA-induced asthma in mice | TGF-β1, MMP9, VEGF |
| Artesunate [65] | OVA-induced asthma in mice | MAPK |
| Ginkgolic acid [66] | Pulmonary fibrosis in mice | Smad4 |
|
