Review Article

Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression

Table 1

Herbal medicine that acts on EMT in different respiratory symptoms.

HerbsFormal nameEnglish nameRespiratory symptomsEMT-related target

Huangqi–Fangfeng [2]Huang qi (Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao)Astragali radixHDM-induced asthmaTGF-β1
Fang feng (Saposhnikovia divaricata (Turcz.) Schischk)Saposhnikoviae radix

Shenqi Cordyceps capsules [38]Xi yang shen (Panax quinquefolium L)Panacis quinquefolii radixPulmonary fibrosis in rats induced by intratracheal instillation of bleomycinα-SMA
Dong chong xia cao (Cordyceps sinensis (BerK.) Sacc)Cordyceps
San qi (Panax notoginseng (Burk.) F. H. Chen)Notoginseng radix et rhizoma

KuShen–GanCao formula [39, 40]Kushen (Sophora flavescens Ait)Sophorae flavescentis radixPulmonary fibrosis in ratsIL-6, IL-17, TGF-β1
Gancao (Glycyrrhiza uralensis Fisch.)Glycyrrhizae Radix et rhizoma

Yanghe Pingchuan [41]Shu di (Rehmannia glutinosa Libosch.)Rehmanniae radix praeparataEgg albumin-induced asthmatic ratPI3K, PCNA
Yin yanghuo (Epimedium brevicomu Maxim.)Epimedii folium
Danggui (Angelica sinensis (oliv.) Diels)Angelicae sinensis radix
Mahuang (Ephedra sinica Stapf)Ephedrae herba
Zi shi ying (Fluorite)Fluoritum
Rougui (Cinnamomum cassia Presl)Cinnamomi cortex
Baijiezi (Sinapis alba L)Sinapis semen
Lujiaopian (Cervus elaphus Linnaeus)Cervi cornu
Wuweizi (Schisandra chinensis (Turcz.) Baill)Schisandrae chinensis fructus
Taoren (Prunus persica (L.) Batsch)Persicae semen
Zaojiao (Gleditsia sinensis)Gleditsiae sinensis fructus

Soufeng Yuchuan decoction [42]Dangshen (Codonopsis pilosula (Franch.))Codonopsis radixOVA-induced asthma in miceTGF-β1, VEGF
Honghua (Carthamus tinctorius L)Carthami flos
Shanzha (Crataegus pinnatifida Bge.)Crataegi fructus
Mahuang (Ephedra sinica Stapf)Ephedrae herba armeniacae semen
Xingren (Prunus armeniaca L. var. ansu Maxim)Amarum
Juluo (Citrus tangerina Hort.et Tanaka C.erythrosa Tanaka)Citrus reticulata Blanco
Laifuzi (Semen Raphani)Radish Seed
Pipaye (Eriobotrya japonica (Thunb.) Lindl.)Folium eriobotryae
Chantui (Cryptotympana pustulata Fabricius)Cicadae Periostracum
Dilong (Pheretima aspergillum)Pheretima
Bai jiang can (Bombyx mori Linnaeus)Batryticatus
Meng shiLapis chloriti
Gan cao (Glycyrrhiza uralensis Fisch.)Glycyrrhizae Radix et rhizoma

Suhuang antitussive capsule [43]Mahuang (Ephedra sinica Stapf)Ephedrae herbaOVA-induced asthmaIL-13, TGF-β1
Zisuye (Perilla frutescens (L.) Britt)Perillae Folium
Zi su zi (Perilla frutescens (L.) Britt)Perillae fructus
Dilong (Pheretima aspergillu)Pheretima
Pipaye (Eriobotrya japonica (Thunb.) Lindl)Eriobotryae folium
Chantui (Cryptotympana pustulata Fabriciu)Cicadae Periostracum
Qianhu (Peucedanum praeruptorum Dunn)Peucedani Radix
Niubangzi (Arctium lappa L)Arctii Fructus
Wuweizi (Schisandra chinensis (Turcz.) Baill)Schisandrae chinensis fructus

Pingchuan I formula [44]Xuan fu hua (Inula japonica Thunb)Inulae flosAsthma in micePDGF-B and Erk1
Dai zhu shi (Haematite)Haematite
Bai jie zi (Sinapis alba L.)Sinapis semen
Suzi (Perilla frutescens (L.)Britt.)Perillae fructus
Tinglizi (Descurainia sophia (L.) Webb, ex Prantl)Descurainiae semen lepidii semen
Banxia (Pineilia ternata (Thunb.) Breit)Pinelliae rhizoma
Huangqin (Scutellaria baicalensis Georgi)Scutellariae radix
Dilong (Pheretima aspergillum^. Perrier)Pheretima
Gangban (Polygonum perfoliatum L.)Polygoni perfoliati herba

Xiaoqinglong decoction [45]Ma huang (Ephedra sinica Stapf)Ephedrae herbaOVA-induced asthma in miceTGF-β1, IL-13
Bai Shao (Paeonia lactiflora Pall)Paeoniae radix alba
Xi xin (Asarum heterotropoides fr. Schmidt var. mandshuricum (Maxim)・Kitag)Asari radix et rhizoma
Gan jiang (Zingiber officinale Rose)Zingiberis rhizoma
Zhigancao (Glycyrrhiza uralensis Fisch)Glycyrrhizae radix et rhizome
Guizhi (Cinnamomum cassia Presl)Cinnamomi ramulus
Wuweizi (Schisandra chinensis (Turcz.) Baill)Schisandrae chinensis fructus
Ban xia (Pinellia ternata (Thunb.) Breit)Pinelliae rhizoma

Dong chong xia cao [46]Dong chong xia cao (Cordyceps sinensis)CordycepsRats with COPDTGF-β1/Smad2, Smad3
Fuling [47]Fuling (Poria cocos (Schw)Wolf)PoriaBleomycin-induced asthmatic ratTGF-β1, TNF-α
Yiyiren [47]Yiyiren (Coix lacryma-jobi L. var. mayuen (Roman.)Stap)Coicis semenBleomycin-induced asthmatic ratTGF-β1, TNF-α
Dongguazi [47]Dongguazi (Benincasa hispida (Thunb.))Winter melon seedsBleomycin-induced asthmatic ratTGF-β1, TNF-α
Danshen [48]Danshen (Salvia miltiorrhiza Bge)Radix salvia miltiorrhizaeBleomycin-induced asthmatic ratTGF-β1, TNF-α
Huangqin [49]Huangqin (Scutellaria baicalensis Georgi)Scutellariae radixRats with cigarette smoke-induced COPDPI3K/Akt/NF-κB