Research Article
Risk Factors Associated with Late Failure of Noninvasive Ventilation in Patients with Chronic Obstructive Pulmonary Disease
Table 2
Univariate and multivariate analysis of risk factors associated with late failure of NIV.
| | | Univariate analysis | Multivariate analysis | | OR (95% CI) | | OR (95% CI) | |
| | Age, years | 1.05 (1.01–1.08) | <0.01 | — | — | | APACHE II score | 1.11 (1.05–1.18) | <0.01 | — | — | | Nosocomial pneumonia during NIV | 21 (4–103) | <0.01 | 75 (11–537) | <0.01 | | Data collected at NIV initiation | | GCS | 0.70 (0.57–0.86) | <0.01 | — | — | | Heart rate, beats/min | 1.02 (1.01–1.04) | <0.01 | 1.04 (1.01–1.06) | <0.01 | | MAP, mmHg | 0.98 (0.96–0.99) | <0.01 | — | — | | PaCO2, mmHg | 0.98 (0.97–1.00) | 0.01 | — | — | | Data collected at 1–2 h of NIV | | GCS | 0.50 (0.36–0.70) | <0.01 | 0.50 (0.34–0.73) | <0.01 | | Respiratory rate, breaths/min | 1.08 (1.01–1.14) | 0.02 | — | — | | Heart rate, beats/min | 1.03 (1.01–1.04) | 0.01 | — | — | | pH at 1–2 h of NIV, per decrease of 0.05 from 7.35 | 1.67 (1.26–2.25) | <0.01 | 2.06 (1.41–3.00) | <0.01 | | PaO2/FiO2, mmHg | 0.993 (0.988–0.998) | <0.01 | 0.992 (0.986–0.998) | 0.01 |
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OR = odds ratio; CI = confidence interval; NIV = noninvasive ventilation; GCS = Glasgow coma scale; MAP = mean arterial pressure.
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