Case Report
Novel Treatment of Disseminated Coccidioidomycosis in a Dog with Voriconazole
Table 1
Modified MSG score. The MSG score is a composite score, comprising the sum of points assigned by the following characteristics: (1) a clinical signs score, with 1 point given for each sign listed; (2) a radiographic imaging scoring system, with points assigned for the size of the abnormality, the presence of satellite lesions, associated adenopathy, and changes in size or presence of infiltrates; and (3) serology points, with a complement fixation titer of 1 : 2 assigned 1 point, 1 : 4 assigned 2 points, 1 : 8 assigned 3 points, and so forth. The patient’s response to treatment was classified as either improved, stable, or unresponsive. An improved outcome was defined as one of the following: (1) a score ≤50% of the pretreatment composite score; (2) the unequivocal documentation of clinical improvement; or (3) a 25–49% decrease in the MSG score and the clinician’s impression of improvement. A stable outcome was defined as an unchanged MSG score or one that declined by <25% by the end of follow-up. An unresponsive outcome was defined as one of the following: (1) the MSG score increased (reflecting progressive infection); (2) progress notes reported relapsed or progressing infection; (3) patient stopped therapy because of intolerance or cost.
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