Bilateral Renal Colic as an Initial Presentation of Erdheim-Chester Disease

Figure 2

Histopathological finding of the renal specimen resected by CT-guided Tru-Cut biopsies: hematoxylin-eosin staining revealed a diffuse proliferation of histiocytes associated to lymphocytic and monocellular invasion, as well as important fibrotic involvement ((a) original magnification ×100). Immunochemistry demonstrated that histiocytes were strongly positive for CD68 (b) and negative for CD1a antigen (c) ((b, c) original magnification ×400). Touton-like multinucleated giant cells (arrowheads) are visible on both CD68 (b) and hematoxylin-eosin staining ((d) original magnification ×400).

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