Late-Onset Posttransplant Lymphoproliferative Disorders after Solid Organ Transplantation in Adults: A Case Series and Review of the Literature

Figure 3

Histology and special studies from the left lung transbronchial biopsy (a–d) and brain lesion (e–h) in Case 3. (a) H&E stain (600x). Left lung transbronchial biopsy showing an atypical polymorphous lymphoid infiltrate containing scattered large Hodgkin/Reed-Sternberg cells within a mixed inflammatory background. (b–d) Immunohistochemical stains (400x) on the lung lesion show that the scattered large atypical cells are positive for CD30 (b), positive for BCL6 (c), focally positive for CD20 (d), but negative for CD45 (not shown). The tumor cells are also positive for EBER by in situ hybridization (not shown). (e) H&E stain (600x). Brain lesion also showing classic Reed-Sternberg cells (arrow). (f–h) Immunohistochemical and in situ hybridization studies (400x) on the brain lesion also show large tumor cells positive for CD30 (f), CD15 (subset) (g), and EBER (h).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)