Case Report

Primary Cytomegalovirus Infection Causing Guillain-Barré Syndrome in a Living Renal Allograft Recipient

Table 1

Summary of cases with cytomegalovirus infection associated with Guillain-Barre Syndrome in renal transplant recipients.

CasesLocationAge of recipientGender of recipientType of kidney transplantCMV serostatus recipient/donorCMV prophylaxisTime after transplant when CMV infection developedImmunosuppression regimenInductionAntiviral medication used for treatmentIVIG dose used for treatmentUse of plasmaOutcome

Drachman et al. 1970 [4]US28MaleCadavericNS/ NSNS5 monthsPrednisone, azathioprineNoneNoNoNoFull recovery

Bale et al., 1980 [5]USA40MaleLivingNS/ NSNS3 monthsPrednisone and 3 days of radiationNSNoNoNoNS

Donaghy et al., 1989 [6]UK48MaleCadavericD+/R−NS7 weeksSteroids, azathioprine, cyclosporineNSNSNSNSNS

De Maar et al. 1999 [7]Netherlands58MaleCadavericD+/R−NS3 monthsCyclosporine, mycophenolate, prednisoloneNoneGanciclovir at a dose of 5 mg/kg every 12 h for 21 days5 dosesNoFull recovery

El Sabrout et al. 2001 [8]Texas44MaleCadavericD+/R−2-week preemptive course of ganciclovir followed by 3 months of oral acyclovir2 years, 2 monthsMycophenolate mofetil, received for acute rejection of OKT3NSSteroids, no improvementNoNoPartial recovery

El Sabrout et al. 2001 [8]USA47MaleCadavericD+/R−NS~7 yearsUnknown, received for acute rejection of OKT3NSIV ganciclovir 5 mg/kg × 14 days6 dosesNoFull recovery

Keithi-Reddy et al. 2007 [9]India48MaleCadavericD−/R−NS3 months postPrednisolone, cyclosporine, mycophenolate mofetilNSIV ganciclovir 5 mg/kg every 12 hours for 21 days5 dosesNoFull recovery

Alvarez et al. 2010 [10]Spain62MaleUnknownNSNS2.5 monthsSteroids, tacrolimus, mycophenolate mofetilNSIV ganciclovir5 dosesNoFull recovery

Alvarez et al. 2010 [10]Spain22FemaleCadavericD+/R−NS5 weeksSteroids, tacrolimus, mycophenolate mofetilNSIV ganciclovir5 doses4 cycles of plasmapheresisFull recovery

Papasotiriou et al. 2013 [11]Greece28NACadavericD+/R−IV ganciclovirfor 2 weeks, then 3 months with valganciclovir190 daysPrednisone, tacrolimus, mycophenolate mofetilBasiliximab, solumedrolIV ganciclovir for 21 days. Then valacyclovir after 21 days. After 2 weeks, foscarnetNo IV IGNoHad a relapse, then full recovery

Shaban et al. 2016 [12]USA62FemaleCadavericD+/R−Valganciclovir for 6 months7 monthsTacrolimus and prednisoneBasiliximab and steroidsIV ganciclovir for 21 days6 dosesNoFull recovery

NS = not specified, D = donor, and R = recipient.