Case Report

Hepatocellular Neoplasm of Uncertain Potential of Malignancy or Well-Differentiated Hepatocellular Carcinoma Arising within Hepatocellular Adenoma

Table 1

Immunohistochemical study of the tumor.

Peripheral areaCentral area

CD34
Clone QBEnd-10, Leica, 1 : 100 dilution±+++ (Sinusoidal capillarization pattern)
GS
Clone 6, BD Transduction Laboratories™, 1 : 600 dilution+ (Heterogeneous)++ (Diffuse)
SAA
Clone mc1, Dako, 1 : 100 dilutionInconclusiveInconclusive
CRP
Clone y284, Abcam, 1 : 500++++++
LFABP
Clone EPR20464, Abcam, 1 : 1,000Preserved in neoplastic cellsPreserved in neoplastic cells
Glypican-3
Clone GC33, Ventana Medical Systems, pre-diluted
HSP-70
Clone W27, NeoMarkers, 1 : 100
Beta-catenin
Clone 14, Cell Marque, pre-diluted+ (Membranar)+ (Membranar)
CK7
Clone SP52, Ventana Medical Systems, pre-diluted+ (Biliary ducts)− (Absence of biliary ducts)
CK19
Clone A53-B/A2.26, Cell Marque, pre-diluted