Study/publication year No. of grade I meningioma patients treated with SRS as primary for presumed grade I or adjuvant after surgery No. of patients who had radiological progression after SRS Number of operated patients after SRS and progression Reported histologic vs. presumed grade I meningioma before SRS Histopathological confirmation after surgery Grade progression to WHO grade II or III Time to progression post-SRS. Mean or Median in months (Range) Park et al. [26 ], 2018 200 28 (14%) 8 Mixed Yes No 62 (range 49-104) M. R. Patibandla et al. [2 ], 2018 120 13 (10.8%) 2 Mixed NR Not reported (52-84) J. W. Kim et al. [14 ], 2017 89 5 (5.6%) 3 Mixed Yes No (75-164) Pollock et al. [7 ], 2017 316 7 (2.2%) 7 Histologic Yes Yes (7) (33.6–165.6) Kim et al. [24 ], 2016 865 56 (6.47%) 8 Presumed Yes Yes (6/8) (36-228) Lee et al. [3 ], 2016 113 9 (7.9%) 4 (3.5%) Presumed Yes Yes (4) CK Jang et al. [1 ], 2015 628 28 (4%) 9 Mixed (128 has) 1 reported Yes (1) (1-79) J. P. Sheehan et al. [5 ], 2015 675 59 (8.8%) 24 Mixed (292 has) Yes No R. M. Starke et al. [17 ], 2015 75 12 (16%) 5 Mixed (45 has) Yes No 78 (6–252) C.J. Przybylowski et al. [18 ], 2014 34 (>WHO1 patients excluded) 5 (14.7%) NR Histologic NR NR 48.9 (1.6–61.4) Seong-Hyun Park et al. [34 ], 2015 39 4 (10%) 0 Mixed (11 has) — — 57 (16–87) R. Starke et al. [36 ], 2014 254 2-8 8 Mixed (114 has) Yes No 71.1 (6–252) S. H. Park et al. [21 ], 2014 74 2 (3%) 1 Mixed (14 has) NR NR At 14.6 and 17.1 after SRS, respectively Pollock et al. [4 ], 2013 460 24 (5.7%) NR Mixed NR NR (43-74) B. E. Pollock et al. [6 ], 2013 115 6 (5%) 4 Mixed (46 has) Yes No 74 (42–145) D. J. Salvetti et al. [23 ], 2013 42 1 (2.4%) 0 Mixed (19 has) — — 59 (12–144) F.A. Zeiler et al. [37 ], 2012 30 2 (7.7%) 0 Mixed (12 has) — — 36.1 (3-80) B. E. Pollock et al. [38 ], 2012 251 3 (1.2%) 02 Presumed — — At 28, 145, and 150 months, respectively Santacroce et al. [19 ], 2012 3768 281 (7.5%) 27 Mixed Yes Yes (8/27) Median, 48.7 R. M. Starke et al. [27 ], 2011 152 19 (13%) 7 Mixed (77 has) NR NR 84 (24–192) M. A. Dos Santos et al. [35 ], 2011 88 9 (10.2%) 0 Mixed (41 has) — — 86.8 (17.1–179.4) K.-W. Jo et al. [10 ], 2011 69 0 0 Presumed — — 63.1 (24–110) Zada et al. [39 ], 2010 136 7 (5.1%) 3 Mixed (72 has) Yes No 90 (60-122) Skeie et al. [13 ], 2010 93 7 (7.5%) 7 Mixed (53 has) NR NR H. Kuroda et al. [40 ], 2009 1 1 1 Histologic Yes Yes (23-33) P. Kunert et al. [11 ], 2009 1 1 1 Presumed Yes Yes 3 months after SRS J.C. Ganz et al. [32 ], 2008 97 0 0 Presumed — — 54 (25–86) Y. Iwai et al. [15 ], 2008 108 18 (16.7%) NR Mixed (62 has) NR Yes (7) 81.8 (20–144) L. Davidson et al. [22 ], 2007 36 1 (2.8%) 1 Histologic NR NR 81 (30–141) A. Kollová et al. [33 ], 2007 368 9 (2.5%) 5 Mixed (109 has) NR NR 60 (24-126) W.T. Couldwell et al. [41 ], 2007 13 13 13 Mixed (10 has) Yes Yes (1) (6-14) Kubo O et al. [8 ], 2005 1 1 1 Histologic Yes Yes — S.J. Dibiase et al. [31 ], 2004 121 10 (8.3%) 1 Mixed (<52 has) NR NR 54 (3.96–126). B.E. Pollock [42 ], 2003 267 6 (2.2%) 5 Mixed (107 has) Yes Yes (2) 43 (2–138) Fuentes et al. [43 ], 2002 1 1 1 Histologic Yes Yes (12-84)
