The Efficacy of Denosumab in the Management of a Tibial Paediatric Aneurysmal Bone Cyst Compromised by Rebound Hypercalcaemia

Table 1

Summary of key lab values that were available at initial, and subsequent, presentations with hypercalcaemia, with levels pre- and post-bisphosphonate treatment.

	Initial presentation	Pre-1^st treatment	Post-1^st treatment	2^nd presentation	Post-2^nd treatment	3^rd presentation	Post-3^rd treatment
Corrected calcium (mmol/L)	4.04	3.53	2.74	3.44	2.50	3.15	2.35
Phosphate (mmol/L)	1.35	1.22	0.70	1.47	0.75	1.33	1.03
ALP (µ/L)	201	204	193	198	158	151	135
Creatinine (µmol/L)	293	179	172	115	99	82	99
PTH (pmol/L)	1.0					<0.3	2.7

Normal ranges: corrected calcium, 2.25–2.74 mmol/L; phosphate, 0.74–1.55 mmol/L; alkaline phosphatase (ALP), 55–236 µ/L; creatinine, 46–102 µmol/L; and parathyroid hormone (PTH), 1.1–6.9 pmol/L.