Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct

Table 1

Immunohistochemical results for each tumor morphology.

Morphology	AE1/3	CK7	Vim	NE	CA19-9	AFP	Hep	CD117	P53	Ki67
Adeno	++	++	−	+	+	Focal	Focal	−	+	50%
Clear cell	+	+	−	Scattered single cells	+	Focal	+	−	+	20%
LCNEC	+	++	−	+	−	−	Focal	+	+	80%
Spindle	Focal	Focal	+	Focal	Focal	−	−	−	+	50%

Adeno: adenocarcinoma; LCNEC: large cell neuroendocrine carcinoma; spindle: spindle cell carcinoma; AE1/3: cytokeratin cocktail AE1/AE3; CK7: cytokeratin 7; Vim: vimentin; NE: neuroendocrine markers chromogranin, synaptophysin, and CD56; AFP: alpha fetoprotein; Hep: Hep Par 1; LCNEC: large cell neuroendocrine carcinoma.