Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Figure 2

Photomicrographs from femur bone biopsy (a) and bone marrow clot preparation (b) showing a monomorphic population of plasma cells intermixed with few small lymphocytes and other hematopoietic cells in the bone marrow. The plasma cells show mature cytological features with strong CD138 reactivity and restriction for kappa light chain. No morphologic evidence of carcinoma is identified in both specimens and staining with cytokeratin marker is negative. [(a) H&E, ×100; (b) H&E, ×400.]