Late Recurrence of Ovarian Cancer after 18 Years of Disease-Free Survival: A Case Report and Review of the Literature

Table 2

Summary of individual studies.

References	Time to recurrence (years)	Age of first treatment	Stage	Initial treatment	Histological type	Recurrence site	Treatment	DFP (months)
Zylberberg et al. [7] (3 cases)	21	33	IIIC	TAH+BSO+OM+excision of visible masses→ten cycles of monthly adjuvant chemotherapy (intraperitoneal and intravenously)	Serous	Appendix	Appendectomy, suboptimal cytoreduction, and chemotherapy	37
	21	50	IC	TAH+BSO+OM, adjuvant chemotherapy		Lower axilla, hepatic nodules, diffuse peritoneal carcinomatosis, and bone metastases	Chemotherapy	19
	26	32	IIIC	Complete cytoreduction, adjuvant chemotherapy, and radiotherapy		Para-aortic lymph node	Laparotomy excision of the mass	36
Sahdev et al. [1] (4 cases)	Ungiven, include a case of 31 years	NA	I, I, IIIC, and unknown	NA	NA	Of 4 cases, 4 pelvic mass, 2 peritoneal, 2 nodal, 2 serosal and mesenteric, 2 ascites, and visceral	Chemotherapy	NA
Testelmans et al. [8]	23	36	NA	TAH+USO and adjuvant chemotherapy	Serous papillary ovarian carcinoma	Thoracic wall	Cytoreduction of the right posterior dorsal thoracic wall, part of the diaphragm, azygos vein, thoracic duct, sympathetic chain, and mediastinal fat; mediastinal lymph node dissection; and local radiotherapy to the mediastinum and the posterior thoracic wall	12
Izuishi et al. [9]	20	32	IIC	TAH+BSO and adjuvant chemotherapy; a year later, second-look surgery, low anterior resection, and adjuvant chemotherapy	Serous papillary adenocarcinoma contained components of a poorly differentiated adenocarcinoma	Spleen	Splenectomy	60
Menczer et al. [10]	28	22	IIIC	TAH+BSO+pOM, adjuvant chemotherapy 1 year after, and “second-look” operation	Serous	Para-aortic retroperitoneal mass	Complete cytoreduction	NA
Otsuka and Shoji [11]	25	29	I	USO (right) during the first trimester of the pregnancy, spontaneous abortion after surgery, adjuvant chemotherapy, and TAH+USO (left)	High-grade endometrioid carcinoma with areas of serous histology	Para-aortic lymph node	Para-aortic lymph node resection, chemotherapy, and radiation	107
Inoue et al. [12]	29	38	III	Radical hysterectomy+OM and adjuvant chemotherapy	Serous	Lung, anterior mediastinum, and liver	VATS, chemotherapy, and subsequently bevacizumab alone	12
Omura et al. [13]	31	23	NA	BSO; 2 years later, uterine metastasis, extended hysterectomy, and adjuvant chemotherapy	Low-grade serous	Thymic epithelial tumor	Partial thymectomy	19
Chiba et al. [14]	41	38	IC	TAH+BSO+pOM and adjuvant chemotherapy	Low-grade serous	Pancreas and liver	Chemotherapy	NA
Takagi et al. [15]	30	46	NA	Radical hysterectomy and adjuvant chemotherapy	High-grade serous	Spleen, peritoneal dissemination, para-aortic and Virchow lymph nodes, intestine, and pouch of Douglas	Partial resection of the intestine; other not mentioned	NA
Current case	18	57	IC	TAH+BSO+pOM and adjuvant chemotherapy	High-grade serous	Spleen and liver	Chemotherapy, hepatic resection (right lobe; segments 5, 6, and 8+splenectomy+cholecystectomy) and adjuvant chemotherapy	56

TAH: total abdominal hysterectomy; USO: unilateral salpingo-oophorectomy; BSO: bilateral salpingo-oophorectomy; pOM: partial omentectomy; NA: none applicable.