Case Report

15-Year-Old Patient with an Unusual Alpha-Fetoprotein-Producing Sertoli-Leydig Cell Tumor of Ovary

Table 1

Cases of SLCT with elevated serum AFP: literature review [6, 811].

ReferencesYear of publicationNo. of casesAge yearDiagnosisHeterologous elementsSerum AFP levels before the surgery (ng/mL) (normal range: 10-20) or (IU/mL) 0.0-5.8 IU/mlLocalization of AFP in tumor

Benfield et al.1982116AndroblastomaIntestinal-type mucinous epithelium400Not performed
Chumas et al.1984116Moderately differentiated SLCTAbsent4 IU/mLLeydig cells
Young et al.1984113Retiform SLCTIntestinal-type mucinous epithelium and hepatocytes14 000Hepatocytes
Sekiya et al.1985121SLCTAbsent109Unidentified cells
Mann et al.1986216/16SLCTAbsent40/62Leydig cells/not interpretable
Tetu et al.1986117Retiform SLCTAbsent256Leydig cells
Tiltman et al.1986127SLCTAbsent153Leydig cells in the recurrence
Chadha et al.1987216/11 monthsSLCT/retiform SLCTIntestinal-type mucinous epithelium and hepatocytes4500/1500Sertoli cells/hepatocytes
Talerman.19872Not availableRetiform SLCTAbsent380-900/7000-11700Sertoli and Leydig cells
Gagnon et al.1989417/16/62/18Retiform SLCT/moderately differentiated SLCTAbsent256/elevated/not availableLeydig cells
Motoyama et al.1989118Retiform SLCTIntestinal-type mucinous epithelium1443Sertoli cells
Taniyama et al.1989155SLCTAbsent105,7Leydig cells
Larsen et al.1992155Bilateral SLCTAbsent200Not performed
Farley et al.1995118Poorly differentiated SLCTAbsent850Not available
Hammad et al.1995117Moderately differentiated SLCTHepatocytes and carcinoid tumor194Hepatocytes
Singh et al.1996117SLCTIntestinal-type mucinous epithelium40Leydig cells
Gard et al.1998117Moderately differentiated SLCTAbsent2682Leydig cells
Mooney et al.1999544/74/18/23/15Moderately or poorly differentiated SLCT with retiform patternHepatocytesNot available but elevatedLeydig cells/hepatocytes
Jang et al.2002126Moderately differentiated SLCTIntestinal-type mucinous epithelium56,6Leydig cells
Gheorghisan-Galatenu et al.2003169Well-differentiated SLCTAbsentNot available but elevatedSertoli cells
Watanabe et al.2008120SLCTIntestinal-type mucinous epithelium306Intestinal-type mucinous epithelium
Poli et al.2009125Bilateral SLCTAbsent101 U/mLSertoli and Leydig cells
Shu et al.201219 monthsModerately differentiated SLCTAbsent22,02 IU/mLNone
Jashnani et al.2013122SLCTAbsent2925Leydig cells
Horta et al.2014119Poorly differentiated SLCTIntestinal-type mucinous epithelium46,3None interpretable
Liang et al.2015115SLCTIntestinal-type mucinous epitheliumNot available but elevatedHepatocytes
Lopez-Arias et al.2015128SLCTHepatocytes636Hepatocytes
Ikota et al.2016112Moderately differentiated SLCTIntestinal-type mucinous epithelium1349,4Not interpretable
Liggins et al.2016140Moderately differentiated SLCTHepatocytes and carcinoid tumorNot available but elevatedHepatocytes
Al-Hussaini et al.2017727/20/7/15/18/18/15Poorly and moderately differentiated SLCTIntestinal-type mucinous glands411/100/elevated/137/686/35.5/185Intestinal-type mucinous epithelium/Leydig cells/none
Xu et al.2018216/16Poorly differentiated SLCTGastrointestinal mucinous epithelium919,8/1881Gastrointestinal mucinous epithelium
Singh C. et al.2018112Poorly differentiated SLCT with heterologous rhabdomyosarcomaHeterologous rhabdomyosarcoma77,1Leydig cells
Strus et al.2019124Moderately differentiated SLCT with glandular mucosa cells of the colonGlandular mucosa cells of the colon10.02 IU/mlGlandular mucosa cells of the colon
Yamamoto et al.2019168Moderately differentiated SLCTHepatocytes and hepatocellular carcinomatous tumor cellsNot availableHepatocytes and hepatocellular carcinomatous tumor cells
Our case115Moderately differentiated SLCTAbsent117Immature hepatocytes