Case Report

Metastasis of Pregnancy-Associated Breast Cancer (Suspected to Be Hereditary Breast and Ovarian Cancer) to the Brain, Diagnosed at 18 Weeks’ Gestation: A Case Report and Review of the Literature

Table 1

Surrogate definitions of the intrinsic subtypes of breast cancer.

Intrinsic subtypeClinicopathologic definition

Luminal ALuminal A
ER- and/or PgR-positive, HER2-negative, and low Ki-67 expression

Luminal BLuminal B (HER2-negative)
ER- and/or PgR-positive, HER2-negative, and high Ki-67 expression
Luminal B (HER2-positive)
ER- and/or PgR-positive, amplified or overexpression of HER2, and high/low Ki-67 expression

Erb-B2 overexpressionHER2-positive (nonluminal)
ER- and PgR-negative and amplified or overexpression of HER2

Basal-likeTriple-negative (ductal)
ER- and PgR-negative and HER2-negative

ER: estrogen receptor; PgR: progesterone receptor.