Successful Treatment of Fetal Intraperitoneal Administration of Immunoglobulin in a Case of Fetal Hemolytic Anemia with 131,072-Fold Anti-E Alloimmunization
Table 1
The clinical course.
Gestational week (w)
Day after birth (d)
Antibody titer
MCA-PSV (MoM)†
Hb (g/dL)
Ht (%)
IgG (mg/dL)
T-Bi1 (mg/dL)
Direct Coombs’ test
Therapy
18
2,048
—
—
—
—
—
—
—
22
2,048
0.71
—
—
—
—
—
—
25
4,096
1.15
—
—
—
—
—
—
27
4,096
1.10
9.1
26.5
243
3.3
positive
IFAC 68 mL
29
4,096
1.67
8.8
25.9
547
2.9
positive
IFAC 68 mL
32
32,768
1.36
8.0
23.8
791
4.5
positive
IFAC 84 mL
33
131,072
0.98
8.5
25.9
1200
4.5
positive
IFAC 100 mL
34
32,768
0.82
8.7
26.6
1410
3.5
positive
IFAC 100 mL
34
32,768
0.95
8.2
25.3
1500
3.8
positive
IFAC 150 mL
35
16,384
1.37
8.3
25.5
2200
3.1
positive
IFAC 100 mL
36
65,536
—
13.6
43.1
8.9
positive
1
12.7
40.3
16.2
2
11.2
32.6
10.6
3
11.9
34.2
12.2
4
11.1
32.3
12.5
5
12.2
36.2
11.1
10
9.7
28.6
10.9
21
8.5
24.6
9.3
MCA-PSV (MoM)†: middle cerebral artery-peek systolic velocity (multiple of median).
