Two Cases of the MYH9 Disorder Fechtner Syndrome Diagnosed from Observation of Peripheral Blood Cells before End-Stage Renal Failure

Figure 1

Upper panels present the control samples; middle panels, case 1 samples; and lower panels, case 2 samples. The May-Giemsa-stained platelets (in the left: original magnification ×1000) show giant platelets from the case 1 and 2 samples. In the May-Giemsa-stained neutrophils (in the middle: original magnification ×1000), the cytoplasmic inclusion bodies (Döhle-like bodies) in the case 1 and case 2 samples are indicated with arrowheads. The nonmuscle myosin heavy chain-II A (NMMHC-II A) distribution in neutrophils is shown in the immunofluorescence micrographs of the neutrophils (in the right). NMMHC-II A is diffusely distributed in the control neutrophils. Arrowheads represent the accumulation of granular NMMHC-II A in neutrophils of cases 1 and 2.