Intravitreal Injection of Anti-VEGF Antibody Induces Glomerular Endothelial Cells Injury

Figure 1

(a) Hematoxylin eosin stained sections show minimal thickening of capillary wall (arrowheads). Arterioles were normal (magnification ×400). (b) PAS stained slide showing a hyaline pseudothrombi (arrows) and segmental microaneurysms filled with pale material (stars). Double contours are visible (arrowheads) (magnification ×400). (c) Jones silver staining showing thickening of the capillary wall (arrows) and double contours (arrowheads). (d) Electron microscopy show focal loss of fenestrations of endothelial cells (arrowheads) and subendothelial space expansion by electron-lucent material (arrow) (magnification ×7000).

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