Case Report
Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation
Table 1
(a) Time series of patient’s laboratory data. (b) Specific data of the patient for aHUS (POD25).
(a) |
| Parameters (unit of measurement) | −1POD | 1POD | 25POD | Normal range |
| White blood cell (/mm3) | 14700 | 3700 | 29900 | 4000–9000 | Hemoglobin (g/dL) | 14.3 | 10.6 | 11.5 | 11.0–15.0 | Platelet (×104/mm3) | 35.4 | 2.1 | 1.3 | 16.1–36.0 | Albumin (g/dL) | 4.8 | 3.0 | 2.8 | 3.9–4.9 | AST (U/L) | 73 | 294 | 126 | 12–29 | ALT (U/L) | 38 | 25 | 8 | 5–29 | LDH (U/L) | 292 | 1167 | 2147 | 106–220 | Total bilirubin (mg/dL) | 0.62 | 2.31 | 2.07 | 0.4–1.3 | BUN (mg/dL) | 9 | 9 | 108 | 9–21 | Creatinine (mg/dL) | 0.18 | 0.33 | 1.18 | 0.80–1.30 | Haptoglobin (mg/dL) | | | <10 | 19–170 | Schizocyte | | | + | (−) | PT-INR | 1.03 | | 2.33 | 1.0 | APTT (s) | 19.9 | | 46.0 | 20–30 | FDP (g/mL) | 2 | | 42 | 0–5 |
|
|
(b) |
| Parameters (unit of measurement) | Results | Normal range |
| C3 (mg/dL) | 40.0 | 86–160 | C4 (mg/dL) | 12.7 | 17–45 | CH50 (IU/mL) | 19.5 | 35–45 | CFH gene mutation | Not detected | Not detected | CFI gene mutation | Not detected | Not detected | CFB gene mutation | Not detected | Not detected | MCP gene mutation | Not detected | Not detected | C3 gene mutation | R425C | Not detected | THBD gene mutation | Not detected | Not detected | Anti-FH antibody | Not detected | Not detected | ADAMTS-13 activity assay | Normal | Normal |
|
|