Postoperative Atypical Hemolytic Uremic Syndrome Associated with Complement C3 Mutation

Table 1

(a) Time series of patient’s laboratory data. (b) Specific data of the patient for aHUS (POD25).

(a)

Parameters (unit of measurement)	−1POD	1POD	25POD	Normal range
White blood cell (/mm^3)	14700	3700	29900	4000–9000
Hemoglobin (g/dL)	14.3	10.6	11.5	11.0–15.0
Platelet (×10^4/mm^3)	35.4	2.1	1.3	16.1–36.0
Albumin (g/dL)	4.8	3.0	2.8	3.9–4.9
AST (U/L)	73	294	126	12–29
ALT (U/L)	38	25	8	5–29
LDH (U/L)	292	1167	2147	106–220
Total bilirubin (mg/dL)	0.62	2.31	2.07	0.4–1.3
BUN (mg/dL)	9	9	108	9–21
Creatinine (mg/dL)	0.18	0.33	1.18	0.80–1.30
Haptoglobin (mg/dL)			<10	19–170
Schizocyte			+	(−)
PT-INR	1.03		2.33	1.0
APTT (s)	19.9		46.0	20–30
FDP (g/mL)	2		42	0–5

(b)

Parameters (unit of measurement)	Results	Normal range
C3 (mg/dL)	40.0	86–160
C4 (mg/dL)	12.7	17–45
CH50 (IU/mL)	19.5	35–45
CFH gene mutation	Not detected	Not detected
CFI gene mutation	Not detected	Not detected
CFB gene mutation	Not detected	Not detected
MCP gene mutation	Not detected	Not detected
C3 gene mutation	R425C	Not detected
THBD gene mutation	Not detected	Not detected
Anti-FH antibody	Not detected	Not detected
ADAMTS-13 activity assay	Normal	Normal