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| Author | Clinical presentation | Diagnosis | Treatment | Outcome |
|
| Hegarty et al. [6] | Fever, diarrhea, and vomiting along with a preceding history of fatigue and flitting polyarthralgia involving the wrists, hands, and feet | SLE, with hypereosinophilia, acalculous cholecystitis, and biopsy-proven eosinophilic vasculitis affecting the kidney | Three consecutive pulses of methylprednisolone (1 g/24 h) | Significant improvement |
| Asadi Gharabaghi et al. [7] | Five-month history of diarrhea and abdominal pain, scalp lesion similar to discoid lupus erythematosus. | Systemic lupus erythematosus with eosinophilic enteritis | Three daily pulses of methylprednisolone at a dose of 1,000 mg/day followed by 0.5 mg/kg/day prednisolone | Symptoms resolved |
| Jaimes-Hernandez et al. [8] | 2 weeks of mild abdominal pain associated with nausea, vomiting, and melena | Eosinophilic enteritis with SLE | Exploratory laparotomy was done and later was diagnosed to be eosinophilic enteritis with SLE. Methylprednisolone pulses 1 g for three consecutive days | Symptoms resolved |
| Thomeer et al. [9] | Polyarthritis, pleuritis and pericarditis, alopecia, skin lesions, photosensitivity, anemia, lymphopenia, periungual vasculitis | SLE with eosinophilia with postmortem diagnosis of Loffler’s syndrome | Methylprednisolone (40 mg/day), chloroquine (100 mg/day), and piroxicam (20 mg/day) | Death |
| Aydogdu et al. [10] | Confusion, quadriparesis, and ataxia | SLE and associated antiphospholipid syndrome with hypereosinophilia and Loffler’s syndrome | 1 mg/kg/day oral methylprednisolone, heparin followed by warfarin and chloroquine | Improved with further no thrombotic events |
| Lee et al. [11] | Malar eruption and extremely pruritic, lichenified papules, and plaques over the trunk and extremities for 2 months, followed by fever, myalgia, chest discomfort, and depressed mood
Proteinuria | Hypereosinophilic syndrome associated with SLE | Prednisolone (60 mg/day) × 3 months
Low-dose prednisolone (10–30 mg/day) × 1 year | Proteinuria-normal
The eosinophil count was still high.
Pruritus persisted and cutaneous lesion did not show improvement |
| Habibagahi et al. [12] | Dizziness, headache, and both upper and lower extremities weakness along with photosensitivity, malar rash, and livedo reticularis | SLE with hypereosinophilia with anticardiolipin antibody positive | Intravenous pulse methylprednisolone and therapeutic doses of heparin
Maintained with 5 mg prednisolone every other day, warfarin (5 mg) and azathioprine (50 mg) per day as a steroid-sparing agent. | Improved |
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