Acute Rhabdomyolysis Associated with Coadministration of Levofloxacin and Simvastatin in a Patient with Normal Renal Function

Table 1

Naranjo’s probability scale for our case.

Naranjo’s algorithm questions	Answer	Score
(1) Are there previous conclusive reports of this reaction?	Yes	+1
(2) Did the adverse event appear when the drug was administered?	Yes	+2
(3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	Yes	+1
(4) Did the adverse reaction reappear when the drug was readministered?	Do not know	0
(5) Are there alternative causes (or other drugs) that could on their own explain the adverse reaction?	Yes	−1
(6) Did the adverse reaction reappear when a placebo was given?	No	+1
(7) Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?	No	0
(8) Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	Yes	+1
(9) Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	Do not know	0
(10) Was the adverse event confirmed by any objective evidence?	No	0
	Total score:	5

The total score calculated from this table defines the category to which an adverse event belongs to.
The categories are defined as shown below:
definite (certain): >8;
probable: total score 5–8;
possible: total score 1–4;
doubtful (unlikely): total score <1.