Review of Two Siblings with Werner's Syndrome: A Case Report

Table 1

Characteristic features of Werner’s syndrome.

Diagnostic criteria by Irwin and Ward [3]	Incidence of features reported (%) in Japanese cases ($n=411$)
Characteristic habitus and stature
Short stature (from adolescence)	86.6
Slender extremities with stocky trunk	86.3
Beak-shaped nose	75.7
Premature senility
Premature grey hair	86.1
Premature baldness	70.0
Atrophic skin	85.4
Weak and high-pitched voice	76.1
Arteriosclerosis	54.0
Juvenile cataracts	94.8
Scleroderma-like changes
Atrophic skin and subcutaneous tissues	86.3
Circumscribed hyperkeratosis	70.5
Ulcers over the malleoli of the ankles,    Achilles tendon, heels, and toes	69.5
Other manifestations
Tendency to diabetes mellitus	67.2
Hypogonadism	64.2
Osteoporosis	54.7
Localised calcification	57.4
Tendency to occur in siblings	48.7

Data obtained by the authors’ search of MEDLINE and Japanese databases in the years from 1916 to 2002.