Lemierre Syndrome: A Diagnosis behind the Veil

Table 2

Duration of therapy and anticoagulation use in Lemierre syndrome case reports from 2016 to 2021.

	Author, year	Antibiotics used	Length of antibiotic course	Anticoagulation/Antiplatelet given	Length of anticoagulation course	Source
1	Laurencet, Marie-Eva et al., 2020	Amoxicillin-clavulanate + clindamycin	6 weeks	Acenocoumarol	12 weeks	[21]
2	Goan, Hannah et al., 2021	Meropenem + vancomycin	N/A	Apixaban + clopidogrel	N/A	[22]
3	Lee, Seung Eun et al., 2021	Amoxicillin-clavulanate + clindamycin	6 weeks	Rivaroxaban	12 weeks	[23]
4	Latif, Azka et al., 2021	Vancomycin + pipera cillin/tazobactam ⟶ vancomycin + doxycycline + meropenem	12 weeks	Apixaban	Not specified	[24]
5	Lanfear, Allison et al., 2020	Ceftriaxone and metronidazole	6 weeks	N/A	N/A	[25]
6	Zhao, Andrew, et al., 2017	Piperacillin/tazobactam + IV vancomycin ⟶ ceftriaxone + metronidazole	N/A	N/A	N/A	[26]
7	Santos, Fabio Videira et al., 2020	Ceftriaxone and metronidazole	2 weeks	Enoxaparin	12 weeks	[27]
8	Jaber, Tariq et al., 2021	Ampicillin-sulbactam + 1 dose of gentamicin ⟶ amoxicillin-clavulanic	6 weeks	N/A	N/A	[4]
9	Jaber, Tariq et al., 2021	Ceftriaxone + azithromycin ⟶ piperacillin-tazobactam and levofloxacin ⟶ piperacillin-tazobactam and clindamycin ⟶ amoxicillin-clavulanate	N/A	Heparin ⟶ warfarin	14 weeks	[4]
10	Jaber, Tariq et al., 2021	Cefepime and metronidazole ⟶ ampicillin-sulbactam ⟶ amoxicillin-clavulanate	6 weeks	Apixaban	12 weeks	[4]
11	Jaber, Tariq et al, 2021	Meropenem and vancomycin ⟶ ampicillin-sulbactam	6 weeks	N/A	N/A	[4]
12	Costa, Fatima et al., 2021	Ceftriaxone, azithromycin ⟶ ? maybe kept at same medication	3 weeks	Heparin ⟶ rivaroxaban	16 weeks	[28]
13	Karn, Michele et al., 2020	Clindamycin, vancomycin, ceftriaxone, and ampicillin/sulbactam ⟶ meropenem	5 weeks	Enoxaparin	5 weeks	[29]
14	Alves, Sergio et al., 2019	Amoxicillin/clavulanate + metronidazole	6 weeks	Enoxaparin	14 weeks	[30]
15	Ngu, Vincent et al., 2018	Amoxicillin/clavulanate ⟶ amoxicillin/clavulanate + metronidazole	2 weeks	Not specified	2 weeks	[31]
16	Dasari, Suhas et al., 2020	IV ceftriaxone and oral metronidazole	4 weeks	Warfarin	12 weeks	[32]
17	Mellor, Thomas et al., 2017	Piperacillin/tazobactam ⟶ ertapenem	4 weeks	N/A	N/A	[33]
18	Gohal, Satan et al. 2021	Piperacillin-tazobactam and clindamycin	6 weeks	Enoxaparin	Not specified	[34]
19	Jawad et al., 2018	Amoxicillin/clavulanate + clarithromycin ⟶ piperacillin-tazobactam + metronidazole ⟶ amoxicillin/clavulanate	6 weeks	Low molecular weight heparin ⟶ rivaroxaban	12 weeks	[35]
20	Gonzalez et al., 2019	Vancomycin and piperacillin/tazobactam ⟶ vancomycin	4 weeks	IV heparin ⟶ oral apixaban	10 days	[36]
21	Garcia et al., 2017	i.v, cefepime, and metronidazole ⟶ IV metronidazole ⟶ amoxicillin‐clavulanate	6 weeks	IV heparin ⟶ warfarin	Not specified	[37]
22	Barguil et al., 2021	Ceftriaxone, metronidazole, and linezolid ⟶ amoxicillin-clavulanic acid	4 weeks	Enoxaparin	4 weeks	[38]
23	Sattar et al., 2020	Meropenem ⟶ piperacillin/tazobactam ⟶ clindamycin	3 weeks	Heparin ⟶ warfarin	Not specified	[39]
24	Howley et al., 2020	Ceftriaxone, vancomycin, and metronidazole ⟶ intravenous ceftriaxone and oral metronidazole	12 weeks	Enoxaparin	12 weeks	[40]
25	Man, Man-Yee et al., 2018	Doxycycline, clindamycin, and vancomycin ⟶ meropenem + doxycycline ⟶ amoxicillin-clavulanate	6 weeks	N/A	N/A	[41]
26	De Oliveira, Rodrigo et al., 2018	Azithromycin, clindamycin, and ceftriaxone ⟶ clindamycin, and ceftriaxone	10 days	N/A	N/A	[12]