Case Report

Atypical Manifestation of VZV Infection in a Vaccinated Immunocompetent Adult

Table 4

Timeline of clinical events.

Day 0Fatigue, headache, nausea, vomiting, and neck stiffness
Day 1The patient was started on IV vancomycin and ceftriaxone. CT head was unremarkable. A lumbar puncture was performed in the emergency room which was suggestive of aseptic meningitis. IV acyclovir started.
Day 2Patient’s headache, nuchal rigidity, nausea, and vomiting significantly improved. Afebrile. CSF PCR positive for VZV. IV vancomycin and ceftriaxone discontinued. The patient continued to be on IV acyclovir
Day 3Near complete resolution of symptoms. Afebrile. IV acyclovir continued
Day 4Asymptomatic, afebrile. On IV acyclovir
Day 5Completed five days of IV acyclovir and discharged home on oral valacyclovir
Day 16Completed nine days of oral valacyclovir; followed up with primary care provider