Two Cases of Post-Traumatic Mucormycosis due to Mucor circinelloides: Salvage Therapy with a Combination of Adjunctive Therapies

Table 2

Characteristic findings of previously reported cases of mucormycosis caused by Mucor circinelloides after trauma or burns.

Case number	Author	Age/sex	Mechanism of trauma	Injury	Underlying predisposing condition	Diagnosis (trauma = D0)	Treatment	Outcome
1	De Paepe et al.	20/male	Road traffic accident	Traumatic amputation of right leg above the knee perineal laceration	None	D14	Surgical debridement, systemic liposomal amphotericin B, HBOT, anidulafungin, local amphotericin B, vacuum-assisted wound closing	Recovered
2	De Paepe et al.	41/male	Road traffic accident	Traumatic amputation of three limbs	None	D10	Surgical debridement, amputation, systemic amphotericin B, vacuum-assisted wound closing	Recovered
3	Holoubek et al. [17]	50/male	Road traffic accident	Subluxation left ankle	None	D24 (D32 Diagnosis of Fusarium sp.)	Surgical debridement, systemic voriconazole, local amphotericin B, vacuum-assisted wound closing	Recovered
4	Schaal et al. [19]	29/N/A	Burn	61% TBSA/52% FTBSA	N/A	2.5 weeks	Systemic amphotericin B, local amphotericin B	Death
5	Schaal et al. [19]	33/N/A	Burn	40% TBSA /30% FTBSA	N/A	4 weeks	Local amphotericin B	Recovered
6	Sekowska et al. [20]	26/male	Road traffic accident	Open knee dislocation, multiple fragment fractures of the left leg	N/A	D3	Systemic amphotericin B, HBOT, amputation	Recovered
7	Chandra et al. [14]	62/female	Minor abrasion	Necrotic ulcer in forearm	Myelodysplastic syndrome	4 weeks	Surgical excision	No recurrence, death from hematological malignancy
8	Fingeroth et al. [15]	23/female	Insect bite	Necrotic lesion	Acute monocytic leukemia	D8	Amphotericin B	Recovered
9–18	Garcia-Hermoso et al. [16]	N/A	Burn	Burn wounds	N/A	N/A	N/A	3 recovered 7 deaths
19-20	Lelievre et al. [18]	Median age 42.9/68.7% male	N/A	Trauma 81.2% involvement of limbs	Underlying disease in 31.2%	Median D15.5	81.2% antifungal therapy,, 93.7% surgery, 18.7% local therapy, 18.7% vacuum-assisted wound closing	37.5% death

TBSA, total body surface area burned; FTBSA, full-thickness burn surface area; N/A, not available; HBOT, hyperbaric oxygen therapy; D, day.