Treating Primary Arthroprosthesis Infection Caused by Mycobacterium abscessus subsp. abscessus

Table 2

Mycobacterium abscessus subsp. abscessus: in vitro antibiotic susceptibility and genome sequencing results. Breakpoints according to CLSI [19].

Antibiotics	07.02.2018	08.07.2018		10.01.2018	10.02.2018
	4-day reading (mg/L)	4-day reading (mg/L)	14-day reading (mg/L)	14-day reading (mg/L)
					23s-wild type-macrolide constitutive resistance not detected
					16s-wild type-susceptible to amikacin erm(41)-wild type-macrolide-inducible resistance detected
Amikacin	3 (S)			16 (S)
Tigecyclin	0.5 (S)			0.75 (S)
Clarithromycin	0.5 (S)	1.5 (S)	4 (R)	4 (R)
Imipenem	4 (S)			32 (R)
Linezolid	8 (R)			>256 (R)
Azitromycin	128 (R)
Moxifloxacin	>32 (R)
Gentamycin	12 (R)

E-test, Middlebrook 7H-11 agar; broth microdilution testing, Middlebrook 7H-9 broth.