Treating Primary Arthroprosthesis Infection Caused by Mycobacterium abscessus subsp. abscessus

Table 1

Microbiology, medical, and surgical treatments.

Date	Microbiology results	Medical therapy	Surgical procedures	Side effects
07/02/2018	Periprosthesis fluid: M. abscessus	Imipenem, teicoplanin	Periprosthetic aspirate
07/11	Periprosthesis fluid: negative	Imipenem, amikacin, clarithromycin	Periprosthetic aspirate
07/12	Prosthesis: M. abscessus + E. faecalis; Periprosthesis bone: negative	Imipenem, amikacin, clarithromycin, linezolid	Prosthesis explanted vancomycin + gentamycin-loaded spacer
07/27		Imipenem, amikacin, clarithromycin	PICC-line positioned
08/09		Imipenem, amikacin, clarithromycin
08/17		Imipenem, amikacin, clarithromycin
09/18		Imipenem, amikacin, clarithromycin
10/20		Imipenem, clarithromycin		Suspected amikacin ototoxicity
10/26		Tigecycline, amikacin		Probable in vitro imipenem resistance
11/10		Imipenem, amikacin		Tigecycline gastric intolerance
11/14	Spacer + bone samples: no growth	Imipenem, amikacin,	Prosthesis reimplant
11/27		Imipenem, amikacin, clarithromycin
12/04		Imipenem, amikacin, clarithromycin
12/05		Imipenem, clarithromycin	PICC-line explanted	Suspected amikacin ototoxicity
12/10		Imipenem, clarithromycin	PICC-line positioned
12/12		Tigecycline, clarithromycin		Tigecycline gastric intolerance and hepatitis
12/20		Clarithromycin
03/01/2019		Clarithromycin	PICC-line explanted	Stop clarithromycin