Autoreactive Antibodies Associated with Castleman Disease Triad

Figure 2

Diagnosis of unicentric hyaline vascular type Castleman disease: (a)–(d) immunohistochemical staining of the retroperitoneal mass showing (a) onionin-skinning and CD21 positive lymphocytes, (b) paracortical vascular penetration, (c) pan-IgG staining, and (d) flow cytometric immunophenotyping tumor biopsy and resection; (e) patient pulmonary function tests; (f) clinical data collected before and after surgery including weight, hemoglobin, white blood cell count, red blood cell count, and platelet count. Vertical dashed red line indicates the date of surgery; (g, h) white blood cell differential by (g) percent and (h) absolute number throughout the clinical course. Green designates to segmented neutrophils. Blue designates lymphocytes. Yellow designates monocytes. Red designates eosinophils. Purple designates basophils. Gray designates immature granulocytes.

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