Omeprazole Induced Rapid Drug Reaction with Eosinophilia, Systemic Symptoms, and Cross-Reactivity in Delayed-Type Hypersensitivity Associated with Proton-Pump Inhibitors: A Case Report and Literature Review

Table 4

Cross-reactivity among proton-pump inhibitors in delayed type hypersensitivity.

Causative PPI/phenotype	Omeprazole	Pantoprazole	Esomeprazole	Lansoprazole	Dexlansoprazole	Rabeprazole
Omeprazole	—	—	—	—	—	—
Pantoprazole/airborne contact dermatitis Pantoprazole/SJS	+P [24]	—	+DPT [22]	—	—	—
Esomeprazole/delayed urticaria esomeprazole/DRESS esomeprazole/MPE esomeprazole/SJS/TEN	−SPT [25] +P [17]	+SPT [25] +P [17]	—	−DPT [25] −DPT [22] −DPT [22] −DPT [22]	−DPT [22]	−DPT [22]
Lansoprazole/pruritic papules lansoprazole/MPE lansoprazole/SJS/TEN lansoprazole/DRESS	+P [26]	−DPT [22]	−DPT [22] −DPT [22]	—	—	+DPT [22]
Dexlansoprazole/MPE	—	—	−DPT [22]	—	—	+DPT [22]
Rabeprazole	—	—	—	—	—	—

Note: DPT, drug provocation test; P, patch test; PPI, proton pump inhibitor; SPT, skin prick test; −, negative result; +, positive result; MPE, maculopapular eruption; SJS/TEN, Stevens–Johnson syndrome/toxic epidermal necrolysis; DRESS, drug reaction with eosinophilia and systemic symptom.