Case Reports in Immunology / 2024 / Article / Tab 4 / Case Report
Omeprazole Induced Rapid Drug Reaction with Eosinophilia, Systemic Symptoms, and Cross-Reactivity in Delayed-Type Hypersensitivity Associated with Proton-Pump Inhibitors: A Case Report and Literature Review Table 4 Cross-reactivity among proton-pump inhibitors in delayed type hypersensitivity.
Causative PPI/phenotype Omeprazole Pantoprazole Esomeprazole Lansoprazole Dexlansoprazole Rabeprazole Omeprazole — — — — — — Pantoprazole/airborne contact dermatitis Pantoprazole/SJS +P [24 ] — +DPT [22 ] — — — Esomeprazole/delayed urticaria esomeprazole/DRESS esomeprazole/MPE esomeprazole/SJS/TEN −SPT [25 ] +P [17 ] +SPT [25 ] +P [17 ] — −DPT [25 ] −DPT [22 ] −DPT [22 ] −DPT [22 ] −DPT [22 ] −DPT [22 ] Lansoprazole/pruritic papules lansoprazole/MPE lansoprazole/SJS/TEN lansoprazole/DRESS +P [26 ] −DPT [22 ] −DPT [22 ] −DPT [22 ] — — +DPT [22 ] Dexlansoprazole/MPE — — −DPT [22 ] — — +DPT [22 ] Rabeprazole — — — — — —
Note : DPT, drug provocation test; P, patch test; PPI, proton pump inhibitor; SPT, skin prick test; −, negative result; +, positive result; MPE, maculopapular eruption; SJS/TEN, Stevens–Johnson syndrome/toxic epidermal necrolysis; DRESS, drug reaction with eosinophilia and systemic symptom.