|
| Reference | PPI drug | Age (year) | Sex | Onset (day) | Presentation | Abnormal tests | Remark |
|
| Carboni et al. [17] | Esomeprazole | 41 | F | 20 | (i) Erythematous and itching skin reaction with maculopapular diffuse lesions, followed by desquamation
(ii) Fever | (i) Eosinophilia
(ii) Hepatitis | Patch tests were positive with esomeprazole, omeprazole, and pantoprazole |
|
| Barbaud et al. [18] | Esomeprazole | 64 | F | NA | NA | NA | Patch test positive |
| Esomeprazole | 60 | M | NA | NA | NA | Patch test positive |
| Pantoprazole | 31 | F | NA | NA | NA | Patch test positive |
| Pantoprazole | 51 | F | NA | NA | NA | Patch test negative |
| Lansoprazole | 75 | F | NA | NA | NA | Patch test negative |
|
| Bourneau-Martin et al. [19] | Omeprazole | 88 | F | 53 | (i) Maculopapular exanthema on the trunk and the face converging with wide patches with purpuric lesions
(ii) Fever
(iii) Lymphadenopathy | (i) Creatinine rising
(ii) Eosinophilia
(iii) Lymphocytosis | Skin biopsy: inflammatory cell infiltrate rich in neutrophils and lymphocytes |
|
| Zaiem et al. [20] | Esomeprazole | 84 | F | 8 | (i) Fever
(ii) Maculopapular rash | (i) Creatinine rising
(ii) Eosinophilia
(iii) Hepatitis | Dead |
|
| Uppalapati and Koneru [21] | Lansoprazole | 40 | F | 30 | (i) Pruritis
(ii) Generalized maculopapular rash
(iii) Palmar erythema | (i) Creatinine rising Eosinophilia
(ii) Hyperbilirubinemia | Skin biopsy showed perivascular inflammatory infiltrate with elevated eosinophils |
|
| Lin et al. [22] | Pantoprazole (n = 2)
Esomeprazole (n = 7)
Lansoprazole (n = 1) | 61.9 ± 8.0 | NA | 27.2 ± 19.1 | (i) Skin rash > 50% of the BSA
(ii) At least one internal organ abnormality
(iii) One blood work abnormality
(iv) Lymphadenopathy
(v) Fever > 38.5°C | (i) Atypical lymphocyte (n = 6)
(ii) Creatinine rising (n = 3)
(iii) Eosinophilia (n = 8)
(iv) Hepatitis (n = 8)
(v) Pneumonitis (n = 3) | — |
|
| He et al. [23] | Omeprazole | 66 | F | 14 | (i) Pruritus
(ii) Desquamation
(iii) Erythema multiforme
(iv) Fever | (i) Creatinine rising
(ii) Eosinophilia | Renal biopsy: chronic tubular interstitial inflammation diffuse atrophy of the renal tubular epithelium, extensive lymphocytic infiltration of the renal interstitial, and occasionally eosinophils |
|
| Present study’s case report | Omeprazole | 82 | F | 4 | (i) Facial erythema
(ii) Facial edema
(iii) Generalized maculopapular rash
(iv) Fever | (i) Hepatitis
(ii) Eosinophilia | ELISpot to omeprazole positive |
|
