Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?

Figure 2

Histology. (a) Lymphomatous infiltration in the bronchial mucosa (hematoxylin–eosin (HE) staining, ×40). (b) Large diffuse large B-cell lymphoma (DLBCL) cells characterized by nuclei with prominent nucleoli on a background of tumoral necrosis (HE, ×400). (c) CD20+ labeling of the DLBCL cells. (d) Epstein–Barr virus-encoded RNA-1 expressed by DLBCL cells.

(a)

(b)

(c)

(d)