Variceal Bleed and Portal Hypertensive Gastropathy in a Noncirrhotic Patient with Isolated Splenomegaly

Table 1

Medication and substance induced causes of noncirrhotic portal hypertension.

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(i) Prehepatic

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 (a) Splenomegaly

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  Granulocyte colony stimulating factor (G-CSF)

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(ii) Hepatic

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 (a) Presinusoidal

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  Vinyl chloride

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 (b) Sinusoidal

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  Methotrexate, amiodarone, vinyl chloride, copper, alcohol

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 (c) Postsinusoidal

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  Gemtuzumab ozogamicin, actinomycin D, dacarbazine, cytosine arabinoside, mithramycin, 6-thioguanine, azathioprine, busulfan, cyclophosphamide, vitamin A, alcohol, pyrrolizidine alkaloids

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(iii) Posthepatic

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 Any agent causing cardiomyopathy or congestive heart failure

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