A Rare Co-Occurrence of Triple Mutations in JAK2, CALR, and MPL in the Same Patient with Myelofibrosis

Table 1

A summary of case reports and case series with multiple driver mutations present in patients with ET and PMF.

No.	Author	N	MPN	JAK2 exon 14	JAK2 exon 12	MPL	CALR	Year
1	McGaffin et al. [15]	1	—	V617F	—	—	Type 6 (48 bp del)	2014
2	Kang et al. [16]	7	ET	V617F	—	—	All types (1, 2, and3)	2016
3	Rashid et al. [17]	1	ET	V617F	—	—	Type 1 (52 bp del)	2016
4	Cleyrat et al. [18]	1	ET	—	—	p.W515R	Type 1 (52 bp del)	2017
5	Jeromin et al. [19]	12	—	V617F	—	Type not reported	—	2017
		6	—	V617F	—	—	Type unreported
		1	—	—	—	Type not reported	Type unreported
6	Usseglio et al. [20]	3	ET	V617F	—	W515L	—	2017
		1	ET	V617F	—	W515R	—
		4	ET	V617F	—	—	Type 1 (52 bp del)
7	Boddu et al. [21]	1	ET	V617F (VAV <1%)	—	—	Type 1 (52 bp del)
8	De Roeck et al. [22]	1	ET	V617F	—	p.W515R	—	2018
		1	PMF	V617F	—	—	Type 1 (52 bp del)
9	Mansier et al. [23]	5	—	V617F (VAF <5%)	—	—	Type unreported	2018
		32	—	V617F	—	—	Type unreported
		11	—	V617F	—	Type not reported	—
		2	—	—	—	Type not reported	Type unreported
		1	—	V617F	Type not reported	—	2 CALR mutations
10	Ramanan et al. [12]	1	—	—	—	p.W515R (VAF 9.8%)	Type 1 52 bp deletion (VAF 13%)	2019
11	Zhou et al. [13]	1	PMF	—	—	p.X636W	CALR-p.364fs	2020

Table 1 is modified from Table 1 of Ramanan et al. [12].