NGS Analysis of Clonality and Minimal Residual Disease in a Patient with Concurrent Richter’s Transformation and CLL/SLL

<div>MRD after allogeneic transplant. Clonal reads were still present at day 30 after allotransplant in total DNA and CD19+ DNA but were extremely few in number to be visualized on the <i>Y</i>-axis. Clonal reads were not detected in total DNA and CD19+ B-cell DNA in peripheral blood (PB) at day 60 after transplant. The B-cell repertoire in the peripheral blood shows successful expansion and diversity at days 30 and 60 after transplant. C: clonal and LQ: LymphoQuant.</div>

Case Reports in Hematology

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Figure 5

Figure 5: NGS Analysis of Clonality and Minimal Residual Disease in a Patient with Concurrent Richter’s Transformation and CLL/SLL 