Case Report
Hemoadsorption Treatment with CytoSorb® in Probable Hemophagocytic Lymphohistiocytosis: A Role as Adjunctive Therapy?
Table 1
Laboratory characteristics.
| | | Normal values | Day 5 | Day 6 | Day 7 | Day 8 | Day 9 | Day 10 | Day 11 | Day 12 | Day 13 |
| | Hematology | | Hemoglobin | 14.0–18.0 (g/dL) | 9.2 | 9.3 | 9.5 | 10.0 | 8.2 | 7.5 | 8.0 | | 7.2 | | Red cells | 4.5–6.0 (G/L) | 3.19 | 3.23 | 3.26 | 3.42 | 2.77 | 2.52 | 2.69 | | 2.38 | | Leucocyte | 4.0–10.0 (G/L) | 3.4 | 4.0 | 4.6 | 7.2 | 4.2 | 3.6 | 2.3 | | 3.4 | | Thrombocyte | 150–450 (G/L) | 53.0 | 44.0 | 49.0 | 49.0 | 34.0 | 33.0 | 26.0 | | 30.0 |
| | Coagulation | | Quick | 70–130 (%) | 110.0 | 110.0 | 94.0 | 70.0 | | | | | 63.0 | | INR | | 0.98 | 0.98 | 1.04 | 1.16 | | | | | 1.22 | | aPTT | 26–36 (sec) | 32.0 | 34.0 | 35.0 | 33.0 | | | | | 42.0 | | Fibrinogen | 1.7–4.1(g/L) | 5.34 | 5.07 | 4.66 | 4.22 | | | | | 5.57 | | D-dimer | <500 (ng/mL) | | >9000 | >9000 | >9000 | | | | | >9000 |
| | Chemistry | | Creatinine | 62–105 (μmol/L) | 92.0 | 100.0 | 98.0 | 69.0 | 60.0 | 57.0 | 95.0 | | 119.0 | | Albumin | 35–52 (g/L) | | 19.0 | 22.0 | 19.0 | 27.0 | 32.0 | | | 22.0 | | Total bilirubin | <21 (μmol/L) | 7.5 | 7.0 | 9.6 | 8.6 | 13.5 | 14.6 | 18.4 | | 10.1 | | Ferritin | 30–50 (ng/mL) | 12209 | | 11586 | 14299 | 9616 | | 14231 | | 25408 | | LDH | 135–225 (U/L) | | 1159.0 | 1461.0 | 1354.0 | 1177.0 | 1292.0 | 1898.0 | | 2099.0 | | CK | 39–308 (U/L) | | 221.0 | 242.0 | 243.0 | 234.0 | 239.0 | 307.0 | | 349.0 | | GOT | 10–50 (U/L) | | 133.0 | 152.0 | 119.0 | 136.0 | 131.0 | 240.0 | | 253.0 | | GPT | 10–50 (U/L) | | 51.0 | 43.0 | 35.0 | 33.0 | 26.0 | 41.0 | | 59.0 | | Lipase | 13–60 (U/L) | | | | 77.0 | 85.0 | 356.0 | 183.0 | | 28.0 | | Calcium | 2.13–2.65 (nmol/L) | | | | 2.56 | 2.44 | 2.45 | | | 2.28 | | Phosphate | 0.81–1.45 (nmol/L) | | | | 1.54 | 1.58 | 1.48 | 1.88 | | 2.59 | | CRP | <5 (mg/L) | 349 | 343 | 335 | 155 | 108 | 146 | | | 601 | | Procalcitonin | <0.05 (μmol/L) | 1.21 | 1.16 | 1.49 | 1.74 | 1.56 | 1.18 | 1.3 | | 15.1 |
| | Immunology | | IFNγ | <15 (ng/L) | 9.8 | 14.9 | 11.2 | 3.3 | 3.8 | 9.6 | | | | | IL8 | <31.2 (pg/mL) | 963 | 1137 | | 499 | 497 | 1064 | | | | | IL6 | <6.4 (pg/mL) | 79.5 | 67.4 | 183.4 | 45.1 | 30.6 | 807 | | | |
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Laboratory characteristics. Days 7–9 correspond to CytoSorb® adsorbent application through CVVHDF.
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