Successful Control of Hepatitis B Virus Reactivation following Restart of Ibrutinib in Chronic Lymphocytic Leukaemia

Table 1

Time course of blood values obtained before, during, and after reactivation.

	February 16	April 16	May 16	June 16 (admission to hospital)	June 16 (ibrutinib paused, tenofovir prescribed)	June 16	August 16 (ibrutinib reinitiated with tenofovir)	October 16	January 17	January 18
P-AST (U/L)	30						28		23	16
P-ALT (U/L)	22						27		18	24
P-ALP (U/L)		80	79				83		75	67
P-BILI (μmol/L)		9	7				12		7	13
P-INR		1.2					1.1
HBV-DNA (IU/mL)					12 000 000				<20	<20

Reference ranges: AST (15–35 U/L), ALT (10–45 U/L), ALP (35–105 U/L), bilirubin (5–25 μmol/L), and INR (0,8–1,2).