Intermediate between Idiopathic Hypereosinophilia and Chronic Eosinophilic Leukemia: A Report of Two Hypereosinophilic Cases with Possible Novel Molecular Mutations

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Author</td><td class="align_center">Frequency of mutation</td><td class="align_center">Genes involved</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Wang et al.</td><td class="align_center">28%</td><td class="align_center">ASXL1, TET2, EZH2, SETBP1, CBL, NOTCH1 DNMT3A, NRAS, JAK2 exon 13, and GATA2</td></tr><tr><td class="align_left">Lee et at.</td><td class="align_center">53%</td><td class="align_center">NOTCH1, TP53, TET2, EZH2, FLT3, IKZF1, ITPKB, SAMHD1, SF3A1, STAG2, ZMYM3, CDKN2A, ATRX, DIS3, BRD4, CARD6, GATA2, NFKBIE, SMC1A, ASXL1, ATM, BIRC3, CBL, CCND1, CEBPA, FAM46 C, FAT4, FBXW7, GATA1, MAPK1, MPL, NF1, PRKD3, PRPF40 B, RUNX1, SCRIB, SF1, SF3B1, SH2B3, SMC3, WT1, PTEN, MED12, BCOR, CSF1R, CSF3R, DNMT3A, EGR2, HIST1H1E, JAK2, LRP1B, POLG, PRKD3, PRPF40 B, RB1, SETBP1, SMARCA2, SMC3, TGM7, U2AF2, and ZRSR2</td></tr><tr><td class="align_left">Choudhuri et al.</td><td class="align_center">—</td><td class="align_center">FBXW7, KMT2A, TCF3, ASXL1, ERBB4, and MET</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Mutations identified in the literature.</div>

Case Reports in Hematology

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Table 2

Table 2: Intermediate between Idiopathic Hypereosinophilia and Chronic Eosinophilic Leukemia: A Report of Two Hypereosinophilic Cases with Possible Novel Molecular Mutations 

Table 2 | Intermediate between Idiopathic Hypereosinophilia and Chronic Eosinophilic Leukemia: A Report of Two Hypereosinophilic Cases with Possible Novel Molecular Mutations 