Intermediate between Idiopathic Hypereosinophilia and Chronic Eosinophilic Leukemia: A Report of Two Hypereosinophilic Cases with Possible Novel Molecular Mutations

Table 1

Demographic and mutation analysis result in two cases of idiopathic hypereosinophilia.

Age (years)/gender	Mutations	Nucleotide change	Allele frequency (%)	Tier	Karyotype/FISH analysis
17/F	FBXW7	c.566_567delAAinsGT; p.K189S	45	1	46, XX
	KMT2A	c.3634 + 4G > A	48	1	No rearrangement of PDGFRA (4q12) and PDGFRB (5q31)
	TCF3	c.1357G > A; p.A453T	51	1	FGRFR1 (8p11)
	TCF3	c.635C > T; p.A212V	51		MDS/MPN FISH panel: negative
33/F	ASXL1	c.2866C > T; p.L956F	47	1	46, XX
	MET	c.467C > T; p.S156L	49	1	FGRFR1 (8p11)
	ERBB4	c.644A > C; p.E215A	53	1	No rearrangement of PDGFRA (4q12) and PDGFRB (5q31)

FISH panel for MDS/MPN includes the following probes: EGR1, D7Z1, D7S486 (7q31), D8Z2 (8 CEN), KMT2A (MLL), TP53, D17Z1 (17CEN), D20S1157 (20PTEL18), D20S108 (20q12), PDGFRA, PDGFRB, CSF1R, FGFR1, CEP 9, ABL1, BCR, D13S319 (13q14.3), and LAMP1 (13q34) (Vysis FISH Probes, Abbott Molecular).