Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review

Figure 2

(a) Spontaneous hypodense areas with intense cortical contrast enhancement in bilateral insulae, anterotemporal predominance of the left grooves, engorgement of the left choroid plexus, right cerebellar tent, the right side of the prepontine cistern and pituitary gland, supratentorial ventricular dilatation with transependymal edema, focal area of lower density in the body of sphenoid, and extensive leptomeningeal infiltration. (b) 35 cells (87% neoplastic plasma cells). (c) 1p32/1q21 copy number changes evaluated by FISH: 1p32, green; 1q21, red and 1q21 gain (100%).

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