Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review

Table 1

Review of published cases of aplastic anemia after thymectomy.

Authors	Ref.	Sex/age	Treatment for thymoma	Interval between thymoma and AA	Progress of blood disorder	Associated diseases	Treatment for AA	Effect
Kobayashi et al.	[4]	F/63	TMT + RT	4 years	ITP ⟶ AA	ND	Splenectomy + CyA	E
Dinçol et al.	[5]	M/38	TMT	3 months	AA	ND	CyA + ATG + mPSL + G-CSF	E
Ritchie et al.	[2]	M/50	TMT + CT + RT	1 year	AA	Myasthenia gravis	mPSL + CyA + ATG	E
Park et al.	[3]	F/61	TMT	16 months	AA	ND	CyA	E
Maslovsky et al.	[6]	M/42	TMT + CT	12 months	PRCA + AT ⟶ AA	Myasthenia gravis	ND	ND
Bajel et al.	[7]	M/67	TMT	6 months	AA	ND	CyA + ATG	E
de Castro et al.	[8]	M/69	TMT	3 years	AA	ND	CyA	E
		F/59	TMT + RT	2 years	AA	ND	CyA + PDN	NE
Simkins et al.	[9]	F/61	CT + TMT	3 months	PRCA + AT ⟶ AA	ND	ATG + mPSL + CyA ⟶ SCT	NE/E
Dahal et al.	[10]	M/63	TMT + CT + RT	More than 3 years	PRCA + AT ⟶ AA	ND	CyA	ND
Present case	—	M/53	TMT	3 years	AT ⟶ AA	ND	CyA + PDN ⟶ SCT	NE

Ref.: reference; AA: aplastic anemia; age: age at diagnosis of AA; TMT: thymectomy; CT: chemotherapy; RT: radiotherapy; CyA: cyclosporin A; ITP: immune thrombocytopenia purpura; ATG: antithymocyte globulin; PDN: prednisone; mPSL: methylprednisolone; ND: not described; NE: not effective; E: effective; PRCA: pure red cell aplasia; AT: amegakaryocytic thrombocytopenia; AA: aplastic anemia; G-CSF: granulocyte-colony stimulating factor; SCT: stem cell transplantation.